Publications by authors named "Carolyn B Rosenthal"
PLoS Pathog
September 2014
Article Synopsis
- Staphylococcus aureus agglutinates in human plasma, aiding its ability to cause disease, but the exact mechanisms involved are not fully understood.
- Researchers developed new methods to study this agglutination and found that the ArlRS two-component system is crucial for this process when exposed to human plasma or fibrinogen.
- They discovered that while the ebh gene (related to the Giant Staphylococcal Surface Protein) is up-regulated in arlRS mutants, it negatively impacts agglutination, and manipulating this gene can influence the pathogenesis of S. aureus in models of infection.
