Publications by authors named "Carolyn B Ramwell"
Article Synopsis
- The study examined the long-term survival of pacemaker and defibrillator leads in pediatric patients with congenital heart disease over a 30-year period, revealing overall lead survival rates of 87% at 10 years and 69% at 20 years.
- It identified factors that contributed to earlier lead failure, including male sex, younger age, significant somatic growth, lead location, and implantation technique.
- The most critical factor linked to lead failure was significant patient somatic growth of 5 cm/year or more, which affected both lead performance and the relationship between demographic characteristics and lead longevity.
Purpose: To determine in children, adolescent and young adult (CAYA) patients presenting with Orthostatic Intolerance (OI) or Postural Orthostatic Tachycardia Syndrome (POTS) associated with the additional symptoms of neuropathic discomfort (pain, paresthesia and/or allodynia): 1) the incidence of small fiber neuropathy, and 2) assess if there was serologic evidence for an underlying inflammatory or autoimmune state.
Methods: A cohort of 109 CAYA patients with the above symptoms underwent epidermal skin biopsy for nerve fiber density. Blood biomarkers for inflammation were tested (CRP, ESR, ANA, complement (C3), thyroid function testing with antibodies (thyroid peroxidase antibody and thyroglobulin antibody), and cytokine panel 13).