Publications by authors named "Carolline M A Lorentino"
Nano-enhanced benzylpenicillin: Bridging antibacterial action with anti-inflammatory potential against antibiotic-resistant bacteria.
Microbes Infect
November 2024
This study investigates the enhancement of benzylpenicillin's antibacterial properties using nanomedicine, specifically by developing benzylpenicillin nanoemulsions. To address the escalating issue of bacterial resistance, we employed the advanced techniques Raman spectroscopy and atomic force microscopy to analyze the nanoemulsions' molecular structure and characteristics. We then evaluated the impact of these nanoemulsions on nitric oxide production by macrophages to deternine their potential to modulate inflammatory responses.
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- Candida species, especially Candida albicans, are the most common fungal pathogens in humans, but there’s been a rise in non-albicans Candida species (NACs) which show increased antifungal resistance.
- Recent research on a copper(II) coordination compound known as CTP has revealed its ability to effectively target and damage antifungal-resistant NACs by affecting their mitochondrial function and causing significant surface alterations.
- CTP not only inhibits biofilm formation by these invasive species but also disrupts established biofilms, making it a promising candidate for developing new antifungal treatments.
Article Synopsis
- Out of 25 tested compounds containing metal ions, 8 showed promise in inhibiting the growth of Candida albicans and Candida tropicalis, with favorable drug-like properties for topical use.
- The complex CTP demonstrated effective antifungal activity against various drug-resistant Candida species with low toxicity in animal models, suggesting its potential as a new treatment option.
The present work aimed to obtain bioproducts from seeds, the Brazilian Caatinga passion fruit, as well as to determine their physical, chemical and biological properties. The seeds were pressed in a continuous press to obtain the oil, which showed an oxidative stability of 5.37 h and a fatty profile rich in linoleic acid.
View Article and Find Full Text PDFHerein, the extraction of bioactive compounds from umbu fruit peel was optimized using thermal-assisted solid-liquid extraction. In parallel, antioxidant, antimicrobial, and inhibitory effects against α-amylase of optimized extract were also evaluated. The combination of operational conditions including the temperature (32-74 °C), ethanol concentration (13-97%), and solid/liquid ratio (1:10-1:60; ) was employed using a rotational central composite design for optimization.
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