Publications by authors named "Carolle Amsellem"
Toxicol In Vitro
March 2010
Article Synopsis
- The 7th amendment of the EU Cosmetics Directive banned animal testing for eye irritation in cosmetics starting March 11th, 2009, prompting the search for alternative testing methods.
- Researchers utilized the SkinEthic HCE model to assess the eye irritancy of 102 cosmetic substances, establishing a prediction model that effectively classified irritants and non-irritants with high sensitivity and specificity.
- The method was further validated with an expanded set of 435 substances, achieving over 82% accuracy and demonstrating its potential as a reliable in vitro tool for predicting eye irritancy, leading to collaborations for prospective validation.
