Publications by authors named "Caroll D Hernandez"
Background: Early microbiota perturbations are associated with disorders that involve immunological underpinnings. Cesarean section (CS)-born babies show altered microbiota development in relation to babies born vaginally. Here we present the first statistically powered longitudinal study to determine the effect of restoring exposure to maternal vaginal fluids after CS birth.
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- FLG loss-of-function variants, particularly R501X and 2282del4, were studied for their role in atopic dermatitis among Chileans, revealing a similar prevalence to European groups.
- In the ARIES cohort, about 6.2% of participants had FLG variants, with slightly higher rates in those with atopic dermatitis (11.1%) compared to those without (5.2%).
- The study found that while FLG variants were not significantly linked to atopic dermatitis, they were associated with an increased risk of asthma in the Chilean population.
Helicobacter pylori colonization may affect the mucosal immune system through modification of microbiota composition and their interactions with the host. We hypothesized that maternal H. pylori status affects the maternal intestinal microbiota of both mother and newborn.
View Article and Find Full Text PDFBackground: Growing evidence shows that atopic dermatitis (AD), food allergy (FA), allergic rhinitis, and asthma are largely determined during the first 1000 days (time elapsed from conception to the 2nd birthday). The ARIES birth cohort aims to determine prenatal and perinatal conditions, as well as genetic and epigenetic factors, that participate in the early setting of immune responses, and the role of these in the later determination of the risk of allergic diseases and asthma in the offspring.
Methods: We have designed a birth cohort of 250 families with prenatal recruitment (~ 14 weeks).