Publications by authors named "Carolini Mendes"

Cost-effective strategies for the treatment of chronic wounds must be developed. The green synthesis of gold nanoparticles (GNPs) it is possible to guarantee a lower toxicity in biological tissues and greater safety of applicability, in addition to adding the effects of nanoparticles (NPs) to those of extracts. The objective of this study was to evaluate the effects of treatment with biosynthesized GNPs in a chronic wound model.

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This study aimed to investigate the effect of intranasal treatment of gold nanoparticles (GNPs) and Curcumin (Cur) on the lipopolysaccharide (LPS)-induced acute pulmonary inflammatory response. A single intraperitoneal injection of LPS (0.5 mg/Kg) was performed, and the animals in the Sham group were injected with 0.

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Chronic wounds represent a challenge for the health area, as they directly impact patients' quality of life and represent a threat to public health and the global economy due to their high cost of treatment. Alternative strategies must be developed for cost-effective and targeted treatment. In this scenario, the emerging field of nanobiotechnology may provide an alternative platform to develop new therapeutic agents for the chronic wound healing process.

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This study aimed to investigate the effects of iontophoresis and hyaluronic acid (HA) combined with a gold nanoparticle (GNP) solution in an excisional wound model. Fifty Wistar rats (n = 10/group) were randomly assigned to the following groups: excisional wound (EW); EW + MC; EW + MC + HA; EW + MC + GNPs; and EW + MC + HA + GNPs. The animals were induced to a circular excision, and treatment started 24 h after injury with microcurrents (300 µA) containing gel with HA (0.

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A perfect graft for wound care must be readily available without affecting the immune response, covering and protecting the wound bed. Considering previous studies have already established the use of hyaluronic acid (HA) for the treatment of wounds but the data presented on the amniotic membrane (AM) and its promising effects on healing still requires further investigation, this study aimed to evaluate the effects of the application of a decellularized amniotic membrane solubilized with hyaluronic acid on the healing process of cutaneous wounds on the 7th and 14th day, to evaluate the evolution of the wound and the inflammatory phases in these two times. Cutaneous lesions were excised from the dorsal region and 96 Wistar rats were divided into four groups: I-Excisional wound (EW); II-EW + AM; III-EW + HA; IV-EW + AM + HA.

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This article aimed to investigate the effects of the association between photobiomodulation and hyaluronic acid incorporated in lipid nanoparticles in an epithelial lesion model in inflammatory parameters and oxidative stress. Eighty Wistar rats were randomly assigned to the following groups: epithelial lesion group (EL); EL+PBM; EL+HA; EL+SLNs; EL+SLNs-HA; EL+PBM+HA; EL+PBM+SLNs; EL+PBM+SLNs-HA. The animals were anesthetized with 4% isofluorane after shaving and induced to an epithelial lesion.

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Photobiomodulation-PBM and Photodynamic Therapy-PDT have been used to induce healing. However, the effects of these therapies on skin-lesions induced by electrocautery are unknown, aiming at more favorable clinical and esthetic results. Electrocauterization was done in 78-female Wistar-rats using a system that includes an electrocautery and red-LED.

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In this study, we performed two experiments. In the first experiment, the objective was to link gold nanoparticles (GNPs) with sodium diclofenac and/or soy lecithin and to determine their concentration in tissues and their toxicity using hepatic and renal analyzes in mice to evaluate their safety as therapeutic agents in the subsequent treatment of obesity. In the second experiment, we evaluated the effect of GNPs on inflammatory and biochemical parameters in obese mice.

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Article Synopsis
  • The study focuses on healing processes for injuries and evaluates the combined effects of Photobiomodulation (PBM) therapy and gold nanoparticles linked to hyaluronic acid (HA) in treating epithelial lesions in rats.* -
  • Results indicated that treated groups exhibited reduced levels of pro-inflammatory cytokines and increased anti-inflammatory cytokines, particularly showing improved outcomes in the group receiving both PBM and GNPs-HA.* -
  • Additionally, oxidative stress markers decreased in treated groups, suggesting that the combination therapy not only aided healing but also enhanced antioxidant defenses compared to the control group.*
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Percutaneous collagen induction (PCI) is an alternative treatment for skin dysfunctions, it aims to stimulate collagen production by encouraging normal wound healing that occurs after any trauma by inducing microlesions; also it may be potentiated with the association with drugs such as hyaluronic acid (HA). Our objective was to evaluate the effects of PCI associated with hyaluronic acid (0.9%) on inflammatory process, oxidative stress, and collagen production in rat epidermis.

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  • The study investigates the therapeutic effects of combining Therapeutic Pulsed Ultrasound (TPU) with diclofenac (DC) linked to gold nanoparticles (GNPs) for treating muscle injuries in rats.
  • Wistar rats were divided into eight treatment groups; those receiving TPU alongside DC and GNPs showed reduced inflammation and oxidative damage in the affected muscle.
  • The combined treatment (TPU + DC-GNPs) not only decreased pain levels but also significantly improved muscle structure and increased antioxidant levels compared to the muscle injury group.
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This study evaluated the effects of omega-3 polyunsaturated fatty acids (PUFAs) on oxidative stress and energy metabolism parameters in the visceral fat of a high-fat-diet induced obesity model. Energy intake, body mass, and visceral fat mass were also evaluated. Male Swiss mice received either a control diet (control group) or a high-fat diet (obese group) for 6 weeks.

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  • The study investigates the effects of ibuprofen phonophoresis combined with gold nanoparticles on muscle repair after traumatic injury in a rat model.
  • Eight groups of male Wistar rats were created, with one group receiving the combination of therapeutic pulsed ultrasound, ibuprofen, and gold nanoparticles, which demonstrated significant improvements in inflammation and pain compared to the muscle injury group.
  • Results showed this treatment reduced pro-inflammatory cytokines and oxidative stress while enhancing anti-inflammatory responses and muscle structure, suggesting potential therapeutic benefits for muscle injuries.
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Alzheimer's disease (AD) is characterized by amyloid (A)β peptide accumulation and intracellular neurofibrillary tangles. New hypotheses have suggested that AD involves neuroinflammation and oxidative stress. Gold nanoparticles (AuNP) presents anti-inflammatory and antioxidant characteristics.

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Article Synopsis
  • The study focuses on the effects of bacterial lipopolysaccharide (LPS), a toxic compound from gram-negative bacteria, on pulmonary inflammation and cellular damage in Wistar rats.
  • Researchers explored whether gold nanoparticles (GNPs) could mitigate the inflammatory response and oxidative stress caused by LPS.
  • Findings showed that GNPs not only reversed LPS-induced tissue changes and inflammation markers without toxicity but also exhibited anti-inflammatory and antioxidative properties beneficial for lung health.
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  • The study aimed to explore how different doses of photobiomodulation (PBM) affect mitochondrial respiratory complexes and energy metabolic enzymes in brain, muscle, and C6 glioma cells over various time intervals.
  • C6 glioma cells were exposed to an AlGaInP laser at doses of 10, 30, and 60 J/cm² for different durations, followed by biochemical measurements on their energy metabolism.
  • Results indicated that PBM enhances respiratory complex activities in a dose- and time-dependent manner, with significant increases observed in specific complexes across different cell types and conditions.
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  • * This study aimed to assess the anti-inflammatory and antioxidant effects of gold nanoparticles (GNP) on Mdx mice, which are used as a model for DMD, comparing several GNP doses over a 30-day period.
  • * Results showed that chronic GNP treatment decreased inflammation and structural damage in the muscle and enhanced antioxidant defenses by lowering harmful reactive species in the affected tissue.
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In the central nervous system, glial cells protect the brain against neuronal stress by inducing inflammatory responses; namely, intracellular signaling and cytokine production. However, chronic inflammation is often associated with degenerative diseases that can damage hormone signaling and mitochondrial function. Lipopolysaccharide (LPS) induces neuroinflammation by stimulating the production of interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α); moreover, it generates oxidative stress and impairs cognitive functions.

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Type 2 diabetes mellitus has undergone a worldwide growth in incidence in the world and has now acquired epidemic status. There is a strong link between type 2 diabetes and vitamin D deficiency. Because vitamin D has beneficial effects on glucose homeostasis, the aim of this study was to evaluate the influence of vitamin D3 supplementation on the modulation of glycaemic control and other metabolic effects, as well as modulation of genomic instability in patients with type 2 diabetes.

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Gold nanoparticles (GNPs) have antioxidant and anti-inflammatory effects. However, toxicity is still a concern; therefore, it is critical to study both the therapeutic and toxic properties of GNPs. In this study, we evaluated the effects of the intraperitoneal administration of GNPs (20nm, at a concentration of 2.

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