Publications by authors named "Caroline de F Zanon"
Chronic inflammation provides a favorable microenvironment for tumorigenesis, which opens opportunities for targeting cancer development and progression. Piplartine (PL) is a biologically active alkaloid from long peppers that exhibits anti-inflammatory and antitumor activity. In the present study, we investigated the physical and chemical interactions of PL with anti-inflammatory compounds and their effects on cell proliferation and migration and on the gene expression of inflammatory mediators.
View Article and Find Full Text PDFArticle Synopsis
- - The success of skin grafts relies on reducing local inflammation and promoting new blood vessel formation, with the N-terminal portion of Annexin A1 (AnxA1) showing promise due to its anti-inflammatory effects.
- - A study investigated the impact of the AnxA1 peptide Ac2-26 on skin grafts in mice, finding that it improved graft acceptance, increased blood vessel formation, and enhanced the levels of key growth factors while balancing inflammatory cytokines.
- - AnxA1 treatment also promoted better migration and proliferation of human endothelial cells, supporting the idea that it facilitates tissue regeneration after skin grafting by managing inflammation and enhancing angiogenesis.
Effect of Melatonin in Epithelial Mesenchymal Transition Markers and Invasive Properties of Breast Cancer Stem Cells of Canine and Human Cell Lines.
PLoS One
July 2016
Cancer stem cells (CSCs) have been associated with metastasis and therapeutic resistance and can be generated via epithelial mesenchymal transition (EMT). Some studies suggest that the hormone melatonin acts in CSCs and may participate in the inhibition of the EMT. The objectives of this study were to evaluate the formation of mammospheres from the canine and human breast cancer cell lines, CMT-U229 and MCF-7, and the effects of melatonin treatment on the modulation of stem cell and EMT molecular markers: OCT4, E-cadherin, N-cadherin and vimentin, as well as on cell viability and invasiveness of the cells from mammospheres.
View Article and Find Full Text PDFPurpose: Galectin-1 (Gal-1) is a β-galactoside-binding protein with diverse biological activities in the pathogenesis of inflammation but has been poorly investigated in terms of ocular inflammation. In the present study, we monitored the anti-inflammatory effects of Gal-1 using the in vivo rodent model of endotoxin-induced uveitis (EIU) and in vitro assays with human RPE (ARPE-19) cells.
Methods: For this purpose, EIU was induced by subcutaneous sterile saline injection of 0.