Literature review and meta-analysis of gastric and intestinal bioaccessibility for nine inorganic elements in soils and soil-like media for use in human health risk assessment.

When soils become contaminated, a human health risk assessment (HHRA) is beneficial for determining whether identified contaminants of potential concern (COPCs) pose a risk to human health. In certain jurisdictions, when calculating doses from soil ingestion during the exposure assessment step of a HHRA, validated bioaccessibility methods may be used to accurately represent a contaminant's relative absorption factor (RAF). Where validated methods do not exist, risk assessors must either a) conduct their own literature search (which can be time consuming), b) create their own validation study (also a time consuming process), or c) use default assumptions (i.

Preclinical evaluation of non-imidazole histamine H3 receptor antagonists in comparison to atypical antipsychotics for the treatment of cognitive deficits associated with schizophrenia.

Cognitive deficits associated with schizophrenia (CDS) are implicated as a core symptom cluster of the disease and are associated with poor daily life functioning. Unfortunately, current antipsychotic agents provide little alleviation of CDS, representing a critical unmet therapeutic need. Here we investigated the effects of ABT-239 and A-431404, non-imidazole histamine H(3) receptor (H(3)R) antagonists, in animal models with relevance to CDS.