Publications by authors named "Caroline Welendorf"
Article Synopsis
- The study aimed to examine the link between specific Single Nucleotide Polymorphisms (SNPs) in the DRD2 and BDNF genes and Binge Eating Disorder (BED) in patients who regained weight after bariatric surgery.
- Researchers evaluated 177 bariatric surgery patients, assessing anthropometric measurements, BED using questionnaires, and genotyping relevant SNPs through real-time PCR.
- Results showed that certain allele variants (CT and TT for DRD2 rs1800497; GA and AA for BDNF rs6265) were more common in patients with BED, suggesting these genetic factors increase the risk of BED, particularly in those who have experienced weight regain.
Background: Telomeres are structures located at the ends of chromosomes associated with a protein complex, known as the shelterin complex. In individuals with obesity, excess adipose tissue plays a key role in inducing a chronic and systemic inflammatory state, which can cause TL shortening. In this context, bariatric surgery is one of the most effective treatment modalities in improving metabolic control.
View Article and Find Full Text PDFBackground: Bariatric surgery, especially Roux-en-Y gastric bypass (RYGB), is the most effective and durable treatment option for severe obesity. The mechanisms involving adipose tissue may be important to explain the effects of surgery.
Methods: We aimed to identify the genetic signatures of adipose tissue in patients undergoing RYGB.
Article Synopsis
- - Telomeres, protective structures at the ends of chromosomes, shorten with each cell division and can be affected by lifestyle choices, especially due to obesity-induced inflammation.
- - The review explores how obesity leads to telomere shortening and identifies key risk factors influencing this process.
- - It concludes that telomere length may serve as a biomarker to measure the effectiveness of weight loss strategies on addressing obesity.