Publications by authors named "Caroline Weiler"
Differential diagnosis between Alzheimer's disease (AD) and cerebral amyloid angiopathy (CAA) using cerebrospinal fluid (CSF) biomarkers is challenging. A recent study suggested that the addition of Aβ38 and Aβ43 to a standard AD biomarker panel (Aβ40, Aβ42, t-tau, p-tau) to improve the differential diagnosis. We tested this hypothesis in an independent German cohort of CAA and AD patients and controls using the same analytical techniques.
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- Cerebral amyloid angiopathy (CAA) is a common condition linked to bleeding in the brain, especially in older adults, and often involves microbleeds that can complicate diagnosis.
- A study reviewed 88 cases of lobar hemorrhages to investigate the presence of deep-seated microbleeds using MRI and histopathological analysis.
- Results indicated that about 15% of patients with histologically confirmed CAA had deep-seated microbleeds, suggesting these findings could help improve identification of CAA cases.
Article Synopsis
- - Cerebral amyloid angiopathy (CAA) and mixed location hemorrhages (MLH) are both associated with lobar hemorrhages, but CAA is characterized by specific features like cortical superficial siderosis (cSS), which is less common in MLH.
- - A study involving patients grouped into CAA, MLH, Alzheimer's disease (AD), and healthy controls showed distinct differences in cerebrospinal fluid (CSF) biomarkers, with higher Aß42 levels in healthy individuals compared to those with CAA and AD.
- - The findings indicate that CAA and MLH may coexist in patients and are part of a continuum of diseases influenced by both CAA and hypertensive arteriopathy (HTN
Background: To evaluate the diagnostic accuracy of cerebrospinal fluid (CSF) biomarkers in patients with probable cerebral amyloid angiopathy (CAA) according to the modified Boston criteria in a retrospective multicentric cohort.
Methods: Beta-amyloid 1-40 (Aβ40), beta-amyloid 1-42 (Aβ42), total tau (t-tau), and phosphorylated tau 181 (p-tau) were measured in 31 patients with probable CAA, 28 patients with Alzheimer's disease (AD), and 30 controls. Receiver-operating characteristics (ROC) analyses were performed for the measured parameters as well as the Aβ42/40 ratio to estimate diagnostic parameters.
Background: The key imaging features of cerebral amyloid angiopathy (CAA) are lobar, cortical, or cortico-subcortical microbleeds, macrohaemorrhages and cortical superficial siderosis (cSS). In contrast, hypertensive angiopathy is characterized by (micro) haemorrhages in the basal ganglia, thalami, periventricular white matter or the brain stem. Another distinct form of haemorrhagic microangiopathy is mixed cerebral microbleeds (mixed CMB) with features of both CAA and hypertensive angiopathy.
View Article and Find Full Text PDFMalassezia pachydermatis is associated with dermatomycoses and otomycosis in dogs and cats. This study compared the susceptibility of M. pachydermatis isolates from sick (G1) and healthy (G2) animals to azole and polyene antifungals using the M27-A3 protocol.
View Article and Find Full Text PDFFusarium spp is an opportunistic fungal pathogen responsible for causing invasive hyalohyphomycosis in immunocompromised patients. Due to its susceptibility pattern with a remarkable resistance to antifungal agents the treatment failures and mortality rates are high. To overcome this situation, combination therapy may be considered which must be subjected to in vitro tests.
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