Safety of coagulation factor concentrates guided by ROTEM™-analyses in liver transplantation: results from 372 procedures.

Background: Most centres use fresh frozen plasma (FFP) based protocols to prevent or treat haemostatic disturbances during liver transplantation. In the present study, we used a rotational thrombelastometry (ROTEM™, TEM, Munich, Germany) guided haemostasis management with fibrinogen concentrates, prothrombin complex concentrates (PCC), platelet concentrates and tranexamic acid without FFP usage and determined the effect on 30 day mortality.

Methods: Retrospective data analysis with 372 consecutive adult liver transplant patients performed between 2007 and 2011.