Clot Retraction and Its Correlation with the Function of Platelet Integrin αβ.

Clot retraction results from retractions of platelet filopodia and fibrin fibers and requires the functional platelet αβ integrin. This assay is widely used to test the functions of platelets and fibrinogen as well as the efficacy of fibrinolysis. Changes in clot retraction have been found in a variety of hemostatic abnormalities and, more recently, in arterial thrombosis.