Publications by authors named "Caroline Valibouze"
Aim: The rate of surgical recurrence following ileorectal anastomosis (IRA) in patients with Crohn's disease (CD) remains poorly understood. Most studies were conducted before the advent of biologics. Our aim was to assess the fate of IRA in patients with CD during the biologics era and identify risk factors for endoscopic, clinical, and surgical recurrence.
View Article and Find Full Text PDFEfficacy and tolerability of chitin-glucan combined with simethicone (GASTRAP DIRECT) in irritable bowel syndrome: A prospective, open-label, multicenter study.
World J Gastrointest Pharmacol Ther
May 2024
Article Synopsis
- IBS is a chronic gastrointestinal disorder marked by abdominal pain and altered bowel habits, with limited first-line treatment options focused on specific symptoms.
- GASTRAP DIRECT is a new medical formulation combining chitin-glucan and simethicone, aimed at treating gas-related symptoms in IBS patients.
- In a 4-week trial with 120 IBS patients, 67% reported reduced abdominal pain, along with significant improvements in bloating, distension, and overall quality of life, showing promising efficacy of GASTRAP DIRECT.
Background: Irritable bowel syndrome (IBS) is one of the most frequent and debilitating conditions leading to gastroenterological referrals. However, recommended treatments remain limited, yielding only limited therapeutic gains. Chitin-glucan (CG) is a novel dietary prebiotic classically used in humans at a dosage of 1.
View Article and Find Full Text PDFThe therapeutic management of Crohn's disease (CD), a chronic relapsing-remitting inflammatory bowel disease (IBD), is highly challenging. Surgical resection is sometimes a necessary procedure even though it is often associated with postoperative recurrences (PORs). Tofacitinib, an orally active small molecule Janus kinase inhibitor, is an anti-inflammatory drug meant to limit PORs in CD.
View Article and Find Full Text PDFArticle Synopsis
- Nonoperative treatment for serious injuries caused by harmful substances can be effective and usually doesn't require surgery, leading to low death rates.
- However, keeping damaged tissue can raise the chance of narrowing in the esophagus.
- The study looked at 184 patients and found that voluntary ingestion of the harmful substance, high injury scores, and serious throat issues were key risk factors for developing esophageal narrowing after ingestion.
Background And Aims: Despite the development of medical therapy, nearly 50% of patients with Crohn's disease [CD] undergo surgery during their lifetime. Several studies have suggested some risk factors for postoperative morbidity [POM] after ileocolic resection [ICR]. However, the impact of surgical hospital volume on POM in CD has not been extensively studied.
View Article and Find Full Text PDFBackground: Postoperative recurrence (POR) after ileocecal resection (ICR) affects most Crohn's disease patients within 3-5 years after surgery. Adherent-invasive (AIEC) typified by the LF82 strain are pathobionts that are frequently detected in POR of Crohn's disease and have a potential role in the early stages of the disease pathogenesis. CNCM I-3856 is a probiotic yeast reported to inhibit AIEC adhesion to intestinal epithelial cells and to favor their elimination from the gut.
View Article and Find Full Text PDFBackground: There is growing evidence that failure to rescue (FTR) is an important factor of postoperative mortality (POM) after rectal cancer surgery and surgical approach modified post-operative outcomes. However, the impact of laparoscopy on FTR after proctectomy for rectal cancer remains unknown. The aim of this study was to compare the rates of postoperative complications and FTR after laparoscopy vs open proctectomy for cancer.
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