Dose-Finding in the Development of an LPS-Induced Model of Synovitis in Sheep.

Models of transient synovitis that can be controlled with antiinflammatory and analgesic drugs have been used to study pain amelioration. To this end, we aimed to determine the dose of intraarticularly administered LPS that induced signs of synovitis without systemic signs in clinically healthy male castrated sheep ( = 14). In phase 1, a single dose of LPS (0.