Publications by authors named "Caroline R Kim"
Article Synopsis
- Exercise leads to the secretion of irisin from muscles, which has cognitive benefits and helps combat neurodegeneration.
- A study uncovered that the heat shock protein eHsp90α released during exercise activates the integrin αVβ5, enhancing irisin's ability to bind and signal effectively.
- Researchers created a detailed model of the irisin and αVβ5 interaction, revealing a unique binding site for irisin, which highlights a new way small polypeptide hormones can interact with integrin receptors.
Article Synopsis
- Adaptive thermogenesis can increase energy expenditure and help combat obesity and diabetes by utilizing thermogenic fat cells.
- New research shows that these fat cells use an enzyme called tissue-nonspecific alkaline phosphatase (TNAP) to engage in a process called futile creatine cycling, which releases energy as heat.
- In experiments, inhibiting TNAP reduces energy expenditure and promotes obesity in mice, highlighting its essential role in metabolic processes within thermogenic fat cells.
Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to adipose tissue heterogeneity. Here, we employed single-cell RNA-seq and identified a unique subset of adipocyte progenitor cells (APCs) that possessed the cell-intrinsic plasticity to give rise to beige fat. This beige APC population is proliferative and marked by cell-surface proteins, including PDGFRα, Sca1, and CD81.
View Article and Find Full Text PDFBackground: Non-ER nuclear receptor activity can alter estrogen receptor (ER) chromatin association and resultant ER-mediated transcription. Consistent with GR modulation of ER activity, high tumor glucocorticoid receptor (GR) expression correlates with improved relapse-free survival in ER+ breast cancer (BC) patients.
Methods: In vitro cell proliferation assays were used to assess ER-mediated BC cell proliferation following GR modulation.
Although high glucocorticoid receptor (GR) expression in early-stage estrogen receptor (ER)-negative breast cancer is associated with shortened relapse-free survival (RFS), how associated GR transcriptional activity contributes to aggressive breast cancer behavior is not well understood. Using potent GR antagonists and primary tumor gene expression data, we sought to identify a tumor-relevant gene signature based on GR activity that would be more predictive than GR expression alone. Global gene expression and GR ChIP-sequencing were performed to identify GR-regulated genes inhibited by two chemically distinct GR antagonists, mifepristone and CORT108297.
View Article and Find Full Text PDFTargetable molecular drivers for triple-negative breast cancer (TNBC) have been difficult to identify; therefore, standard treatment remains limited to conventional chemotherapy. Recently, new-generation small-molecule Hsp90 inhibitors (e.g.
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