Publications by authors named "Caroline Pumpe"
Article Synopsis
- During inflammation, increased vascular permeability can lead to harmful effects, especially in inflamed lungs, where microvascular leakage occurs.
- Formylated peptides, which trigger neutrophil activation through FPR1, play a role in regulating this vascular leakage, with research identifying ARAP3 as a protective factor against excessive permeability.
- Studies showed that ARAP3 deficiency in endothelial and immune cells led to increased microvascular leakage and neutrophil activity, hinting at its significance in conditions with high levels of formylated peptides, such as severe influenza.
