Publications by authors named "Caroline Peyraud"
Article Synopsis
- Met4 is a key transcriptional activator for sulfur metabolism in yeast, but it needs to work with specific cofactors since it can’t bind DNA on its own.
- Researchers deleted different cofactors to see how they affect Met4's ability to activate genes, identifying 45 core target genes essential for the metabolic process.
- The study found that Met31 and Met32 are crucial for activating all core genes, while Met28 and Cbf1 influence only certain genes, indicating complex interactions and varying binding behaviors among these cofactors based on specific conditions.
In yeast, the Met4 transcription factor and its cofactors Cbf1, Met28, Met31, and Met32 control the expression of sulfur metabolism and oxidative stress response genes. Met4 activity is tuned to nutrient and oxidative stress conditions by the SCF(Met30) ubiquitin ligase. The mechanism whereby SCF(Met30)-dependent ubiquitylation of Met4 controls Met4 activity remains contentious.
View Article and Find Full Text PDF