Publications by authors named "Caroline Mann"

Article Synopsis
  • Eczema and psoriasis are inflammatory skin diseases that have different molecular causes, necessitating more detailed research to improve diagnosis and treatment.
  • The study used non-invasive skin sampling to analyze proteins in various skin types from individuals with psoriasis and eczema, revealing IL-36γ as a strong biomarker for psoriasis and elafin as a better indicator for distinguishing between the two conditions.
  • Findings show significant differences in protein expression between healthy and diseased skin, with implications for developing targeted therapies based on these molecular markers.
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Pruritus is defined as a symptom that leads to scratching. Clinically, a heterogeneous group of clinical pictures of different etiology must be considered. Pruritus is characterized by varying intensity and duration.

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Article Synopsis
  • * The study measured changes in disease severity, pain levels, and quality of life using specific scoring systems and confirmed that LAight therapy significantly reduced symptoms.
  • * Findings suggest that LAight therapy is effective for managing HS at all severity levels and enhances treatment options for patients.
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Background: Data on the course of urticaria in children exist, but there is a lack of sound data on patient management to ensure high-quality care.

Methods: Retrospective secondary data analysis in the field of health care and epidemiology in children with urticaria based on routine data from a German health insurance company (DAK-Gesundheit). Data from insured persons under 18 years of age who were treated as outpatients or inpatients with a diagnosis of urticaria (according to ICD-10 classification) in 2010-2015 were included.

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The scalp is the most common site affected in patients with psoriasis with up to 80% of these patients having some degree of scalp involvement. In this narrative review, we evaluate available data on the use of an innovative aerosol foam formulation of calcipotriol plus betamethasone dipropionate (Cal/BD) to treat patients with psoriasis and scalp involvement. The full PubMed database was searched using the terms "calcipotriol", "betamethasone dipropionate" and "aerosol foam", and all articles relating to "psoriasis with scalp involvement" were retrieved and used in the preparation of this review.

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Introduction: The prevalence of atopic diseases remains high. Initial studies suggest that primary prevention with regular basic care may influence the incidence of atopic dermatitis in infants; however, data are unclear. Midwives play an important role in the care of women in the peripartum period and therefore also in providing advice on topics such as skin care, breastfeeding and nutrition of the newborn and young infant.

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Introduction: Patients with chronic inflammatory skin diseases often suffer from sleep disturbances. However, objective data on sleep architecture, especially to evaluate potential overall influences under therapy, are lacking.

Patients And Methods: Pilot study on sleep quality changes including psoriasis and atopic dermatitis patients before and 2 weeks after intensive topical treatment.

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Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a bipolar age distribution in childhood, adolescence and middle adulthood. Up to 50% of AD patients show ocular involvement, which can be potentially sight threatening. Clinically, the majority of cases present with atopic blepharo(kerato)conjunctivitis or atopic keratoconjunctivitis (AKC); other clinical variants from this group of inflammatory ocular surface diseases are keratoconjunctivitis vernalis in childhood and adolescence and allergic conjunctivitis.

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Background: There is a lack of real-life safety data on treatment options for chronic urticaria in the presence of comedication and comorbidities.

Methods: We present a single-center UCARE pilot study of 212 outpatients with chronic urticaria. Patients were divided into three groups according to different CU therapies according to international guidelines.

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Lichen planus (LP) presents with a range of clinical subtypes. It can affect the outer skin, involve the nails and present with alopecia and mucosal symptoms to varying degrees. LP of the outer skin mostly shows a self-limiting course; however, this is not the case for lichen planopilaris and the mucosa-affecting subtypes.

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Sleep is a normal physiological process that accounts for approximately one third of a person's life. Disruption of the normal sleep cycle, which maintains physiological homeostasis, can lead to pathology. It is not known whether sleep disturbance causes skin disease or skin disease causes sleep impairment, but a bidirectional influence is suspected.

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Background Frontal fibrosing alopecia (FFA) and lichen planopilaris (LPP) is scarring alopecias with limited evidence supporting their treatment options. We investigated the use of low-dose naltrexone (3 mg oral daily) as adjunctive therapy in the treatment of FFA and LPP. Methods A single-center, uncontrolled open-label prospective study was performed, with 26 patients who took low-dose naltrexone for one year included in the per-protocol analysis.

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The excitatory/inhibitory (E/I) imbalance hypothesis posits that imbalance between excitatory (glutamatergic) and inhibitory (GABAergic) mechanisms underlies the behavioral characteristics of autism. However, how E/I imbalance arises and how it may differ across autism symptomatology and brain regions is not well understood. We used innovative analysis methods-combining competitive gene-set analysis and gene-expression profiles in relation to cortical thickness (CT) to investigate relationships between genetic variance, brain structure and autism symptomatology of participants from the AIMS-2-TRIALS LEAP cohort (autism = 359, male/female = 258/101; neurotypical control participants = 279, male/female = 178/101) aged 6-30 years.

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Background: Standard treatment options for urticaria are second-generation antihistamines; however, their effect on sleep is uncertain. This study measures the influence of different antihistamines on the biologic sleep pattern of urticaria patients and the relevance of sleep in urticaria patients. Methods: Ten patients with chronic spontaneous urticaria (CSU) and uncontrolled symptoms under a single dose of second-generation antihistamines were included.

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Article Synopsis
  • Autism Spectrum Disorder (ASD) shows a range of outcomes, with some individuals improving and others not, emphasizing the need for personalized medicine approaches based on biological processes.
  • A longitudinal study involving 483 individuals assessed behavioral, neuroanatomical, and genetic data to categorize those with ASD into outcome groups: "increasers," "no-changers," and "decreasers."
  • Results revealed distinct neuroanatomical features in these groups, indicating that deviations from a typical neuroanatomical profile can predict individual outcomes, linked to genetic factors related to brain development.
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The neuroanatomy of autism spectrum disorder (ASD) shows highly heterogeneous developmental trajectories across individuals. Mapping atypical brain development onto clinical phenotypes, and establishing their molecular underpinnings, is therefore crucial for patient stratification and subtyping. In this longitudinal study we examined intra- and inter-individual differences in the developmental trajectory of cortical thickness (CT) in childhood and adolescence, and their genomic underpinnings, in 33 individuals with ASD and 37 typically developing controls (aged 11-18 years).

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Article Synopsis
  • - The study investigates the link between brain anatomy and genetics in individuals with autism spectrum disorder (ASD), focusing on differences in cortical thickness across a diverse group of participants.
  • - Results show significant differences in key brain regions between those with ASD and typically developing individuals, revealing neuroanatomical deviations that correlate with genetic predisposition and symptom severity.
  • - Findings support the connection between brain structure and the molecular mechanisms involved in ASD, suggesting pathways for tailored therapeutic interventions and better understanding of the disorder's complexity.
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Background: To date, robust epidemiological metrics as well as data on comorbidity in pediatric urticaria are lacking. They form the basis for the design of efficient healthcare.

Methods: Retrospective study to analyze epidemiological data in pediatric urticaria.

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Unlabelled: As of 31 January 2021, 63.9 million cases and 1.4 million deaths had been reported in Europe and North America, which accounted for 62.

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