HLA-DR expression is associated with better prognosis in sporadic Australian clinicopathological Stage C colorectal cancers.

Predicting patient outcome for colorectal carcinoma (CRC) with lymph node but not distant metastases remains challenging. Various prognostic markers have been identified including microsatellite instability (MSI) and possibly expression of the MHC Class II protein, HLA-DR. About 15% of sporadic CRC exhibits MSI associated with methylation of the DNA mismatch repair gene hMLH1 promoter.

The internal anal sphincter in systemic sclerosis.

Purpose: Fecal incontinence in systemic sclerosis can occur secondary to fibrous replacement of the internal sphincter or ischemic myopathy of internal anal sphincter from vasculitis. Both lead to morphologic changes of the internal anal sphincter on endoanal ultrasound. This study documents the morphologic changes that can occur.

Laparoscopic versus open ileocolic resection for Crohn's disease.

Objective: Laparoscopic ileocolic (LI) resection for Crohn's disease has several potential advantages over the traditional open technique. The objective of this study was to compare early surgical outcomes in patients having laparoscopic versus open ileocolic resections for Crohn's disease.

Methods: Data collected prospectively from 21 patients having LI resection for Crohn's disease between 1995 and 2001 were compared to data from 19 patients having open ileocolic resection for Crohn's disease between 1990 and 1995.