Publications by authors named "Caroline M Meers"
Article Synopsis
- PEEK materials, used in orthopedic surgery, face challenges in bone adhesion due to their low biocompatibility, prompting this study to investigate the impact of titanium and calcium phosphate (CaP) coatings on bone tissue adhesion.
- In a study with six adult sheep, three types of PEEK dowels were implanted: uncoated (control), with CaP coating, and with titanium coating, and then analyzed after different time intervals.
- The results showed that titanium-coated PEEK dowels had significantly greater bone implant contact and bone volume compared to uncoated dowels, indicating that titanium coating enhances the adhesion of bone tissue to these implants.
Background: Donor lungs are susceptible to aspiration in the period before and after brain death. We hypothesized that preemptive anti-inflammatory treatment may result in better graft performance as evaluated during ex vivo lung perfusion (EVLP).
Methods: Pigs (27.
Background: Evidence of aspiration remains a major reason for declining donor lungs contributing to current organ shortage. The aim of the present ex vivo lung perfusion (EVLP) study was to compare lungs injured by gastric juice (GJ) with normal lungs.
Methods: Pigs (32.
Background: About 15% of donor lungs are declined because of aspiration contributing to current organ shortage. The aim was to develop a porcine lung injury model by gastric juice (GJ) instillation to study different pretransplant treatment strategies.
Materials And Methods: Pigs (n = 6/group) were anesthetized and monitored.
Background: Brain death rapidly results in lung injury making many cadaveric donors unsuitable for lung transplantation. The aim of this study was to develop a porcine model of lung injury as a first step to study mechanisms to ameliorate the pretransplant graft quality during ex vivo perfusion.
Materials And Methods: Male pigs (47 ± 8 kg) were divided into three groups: LPS-group [LPS] (n = 6) [instillation of lipopolysaccharides (15 mg/lung)]; saline-group [SAL] (n = 5) (50 mL saline/lung); and sham-group [SHAM] (n = 5).