Publications by authors named "Caroline Kuhlman"
Article Synopsis
- Biliary tract cancers show strong resistance to treatments, and effective therapies for these advanced cases are currently limited.
- A clinical trial combined DKN-01 and nivolumab to see if they could help patients with advanced biliary tract cancer, but no positive results were found.
- Researchers analyzed tissue samples to identify different cell types that contribute to the cancer's resistance, discovering new immune and malignant cell states that could inform future treatment strategies.
Context: Patients with advanced cancer are at increased risk for multiple hospitalizations and often have considerable needs postdischarge. Interventions to address patients' needs after transitioning home are lacking.
Objectives: We sought to demonstrate the feasibility and acceptability of a postdischarge intervention for this population.
Purpose: To assess the efficacy, tolerability, and pharmacokinetics of ecteinascidin 743 (ET-743) in patients with advanced gastrointestinal stromal tumors (GISTs).
Patients And Methods: The study was confined to adult patients with radiographically measurable GISTs. ET-743 was administered as a 24-hour continuous i.