Publications by authors named "Caroline Kornbrek"
Article Synopsis
- The study addresses the limitations in Alzheimer's disease research due to the absence of effective animal models that reflect key disease features such as amyloid deposition, tau aggregation, inflammation, and neurodegeneration.
- Researchers created a dual transgenic mouse model (APPNL-G-F/PS19 MAPTP301S) that exhibited significant pathologies including amyloid plaques, tau pathology, and inflammation at just 6 months of age.
- The findings indicate that amyloid presence worsens tau pathology and inflammation, with specific brain regions showing stronger microglial inflammation and an increase in N-methyladenosine (mA), a modification linked to Alzheimer's, suggesting potential implications for understanding AD's mechanisms.
Mouse pups produce. ultrasonic vocalizations (USVs) in response to isolation from the nest (i.e.
View Article and Find Full Text PDFHumans are extraordinarily social, and social isolation has profound effects on our behavior, ranging from increased social motivation following short periods of social isolation to increased anti-social behaviors following long-term social isolation. Mice are frequently used as a model to understand how social isolation impacts the brain and behavior. While the effects of chronic social isolation on mouse social behavior have been well studied, much less is known about how acute isolation impacts mouse social behavior and whether these effects vary according to the sex of the mouse and the behavioral context of the social encounter.
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