Weight loss in obese girls with polycystic ovarian syndrome is associated with a decrease in Anti-Muellerian Hormone concentrations.

Objective: The Anti-Muellerian Hormone (AMH) has been reported as surrogate marker of antral follicles, which are the origins of hyperandrogenism in polycystic ovarian syndrome (PCOS). Therefore, AMH may be useful for the diagnosis of PCOS. The objective was to study the longitudinal changes in AMH concentrations in girls with and without PCOS.

Effect of Weight Loss on Puberty Onset in Overweight Children.

Objective: To assess the impact of weight changes on the onset of puberty in overweight children.

Study Design: We evaluated the timing of puberty onset in 160 prepubertal overweight children (aged 11.2 ± 1.

Carotid Intima-Media Thickness in Children Treated with Growth Hormone: A Follow-Up Study over Three Years.

Background: There is an ongoing discussion whether high doses of growth hormone (GH) may lead to cardiovascular diseases. Therefore, we studied the longitudinal relationships between GH treatment and carotid intima-media thickness (cIMT), which is predictive of the development of atherosclerosis.

Methods: We measured blood pressure, lipids, hemoglobin HbA1c, IGF-1, IGFBP-3, and cIMT in 28 children treated with supraphysiological doses of GH (mean age 9.

Strong effect of pubertal status on metabolic health in obese children: a longitudinal study.

Context: The concept of metabolic healthy obese (MHO) status has been proposed also for children. However, it is unclear whether this is a stable status in childhood.

Objective: The aim was to analyze the changes of MHO status over time.

Carotid intima-media thickness in children treated with growth hormone.

Background: There is an ongoing discussion whether high doses of growth hormone (GH) may lead to cardiovascular diseases. Therefore, we studied the relationships between GH treatment and carotid intima-media thickness (cIMT), which is predictive of the development of atherosclerosis.

Methods: We measured cIMT in 38 children with supraphysiological doses of GH (mean age 10.

Changes in the serum metabolite profile in obese children with weight loss.

Purpose: Childhood obesity is an increasing problem and is accompanied by metabolic disturbances. Recently, we have identified 14 serum metabolites by a metabolomics approach (FIA-MS/MS), which showed altered concentrations in obese children as compared to normal-weight children. Obese children demonstrated higher concentrations of two acylcarnitines and lower levels of three amino acids, six acyl-alkyl phosphatidylcholines, and three lysophosphatidylcholines.

Relationships between 24-hour urinary free cortisol concentrations and metabolic syndrome in obese children.

Context: Clinical features of Metabolic Syndrome (MetS) and Cushing's Syndrome are similar, suggesting a pathogenetic role of hypothalamus-pituitary-adrenal axis in MetS.

Objective: The aim of the study was to determine whether MetS diagnosis and specific clusters of MetS components (waist circumference, dyslipidemia, hypertension, and impaired glucose metabolism) are associated with serum cortisol (SC) or 24-h urinary free cortisol (UFC) levels.

Design And Setting: We conducted cross-sectional analyses of data from our obesity cohort.

Components of the metabolic syndrome are negative predictors of weight loss in obese children with lifestyle intervention.

Background And Aims: Insulin resistance has been proposed to be associated with weight gain in obesity. Therefore, we analyzed the impact of insulin resistance and its associated cardiovascular risk factors (CRFs) summarized in the Metabolic Syndrome (MetS) on change of weight status in obese children.

Methods: We analyzed 484 obese children who had participated in a lifestyle intervention and 533 obese children without lifestyle intervention.