Modifying the antiviral innate immune response by selective writing, erasing, and reading of mA on viral and cellular RNA.

Viral infection and the antiviral innate immune response are regulated by the RNA modification mA. mA directs nearly all aspects of RNA metabolism by recruiting RNA-binding proteins that mediate the fate of mA-containing RNA. mA controls the antiviral innate immune response in diverse ways, including shielding viral RNA from detection by antiviral sensors and influencing the expression of cellular mRNAs encoding antiviral signaling proteins, cytokines, and effector proteins.