Publications by authors named "Caroline I Larkin"
Unlabelled: Eastern equine encephalitis virus (EEEV) is an arthropod-borne, positive-sense RNA alphavirus posing a substantial threat to public health. Unlike similar viruses such as SARS-CoV-2, EEEV replicates efficiently in neurons, producing progeny viral particles as soon as 3-4 hours post-infection. EEEV infection, which can cause severe encephalitis with a human mortality rate surpassing 30%, has no licensed, targeted therapies, leaving patients to rely on supportive care.
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- The novel coronavirus SARS-CoV-2 is crucial for global public health, but there's limited understanding of how it interacts with the immune system and causes varying disease outcomes.
- Researchers are developing multiscale simulation models to explore these complex interactions and identify potential treatment targets and biomarkers for different patient responses.
- A collaborative effort is creating an open-source model of SARS-CoV-2 dynamics in lung tissue, combining expertise from multiple disciplines to enhance therapeutic discovery and optimize responses to this health crisis.