The development and implementation of a new hospital performance measure to assess hospital contributions to community health and equity.

Objective: To develop and implement a measure of how US hospitals contribute to community health with a focus on equity.

Data Sources: Primary data from public comments and hospital surveys and secondary data from the IBM Watson Top 100 Hospitals program collected in the United States in 2020 and 2021.

Study Design: A thematic analysis of public comments on the proposed measure was conducted using an iterative grounded approach for theme identification.

Assessment of Public Opinion on Transparency at the US Food and Drug Administration.

This survey study assesses public support for or opposition to transparency measures regarding the US Food and Drug Administration (FDA) drug approval process.

Global Regulatory Agencies and Data Transparency.

Egilman et al. review the current data sharing practices of three global regulatory agencies - Health Canada, the European Medicines Agency and the Food and Drug Agency. While there has been progress towards increasing transparency over the past decade, progress has been slow.

Classroom Temperatures and Asthma-Related School-Based Health Care Utilization: An Exploratory Study.

Objective: Schools with aging infrastructure may expose students to extreme temperatures. Extreme outdoor temperatures have previously been linked to more asthma-related health care utilization. Explore the relationship between classroom temperatures and school-based health care visits for asthma in an urban school building with an outdated heating and cooling system.

establishes germline versus soma by balancing inherited histone methylation.

Formation of a zygote is coupled with extensive epigenetic reprogramming to enable appropriate inheritance of histone methylation and prevent developmental delays. In , this reprogramming is mediated by the H3K4me2 demethylase SPR-5 and the H3K9 methyltransferase, MET-2. In contrast, the H3K36 methyltransferase MES-4 maintains H3K36me2/3 at germline genes between generations to facilitate re-establishment of the germline.