Group B -Induced Macropinocytosis Contributes to Bacterial Invasion of Brain Endothelial Cells.

Bacterial meningitis is defined as serious inflammation of the central nervous system (CNS) in which bacteria infect the blood-brain barrier (BBB), a network of highly specialized brain endothelial cells (BECs). Dysfunction of the BBB is a hallmark of bacterial meningitis. Group B (GBS) is one of the leading organisms that cause bacterial meningitis, especially in neonates.

An examination of the levels of confidence that consultants have in routinely collected clinical information.

Anecdotal evidence suggests that consultants have a low level of confidence in routinely collected clinical data. The aims of this study were to assess the actual levels of confidence in clinical information experienced by consultants and to understand the factors affecting confidence. A questionnaire was devised incorporating a scale to measure levels of confidence.