Publications by authors named "Caroline Burkhard"

Article Synopsis
  • In the MAPK pathway, the V600E mutation in B-Raf kinase leads to constant activation, resulting in excessive activity of downstream kinases MEK and ERK, contributing to melanoma and other cancers.
  • Research indicates that existing drugs often fail due to resistance and can paradoxically activate B-Raf; therefore, new drugs targeting allosteric sites are necessary.
  • By studying a specific α-helix on B-Raf crucial for its interaction with MEK, the research identifies potential new drug targets to inhibit B-Raf's oncogenic effects in melanoma.
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