Publications by authors named "Caroline Bronchick"

Article Synopsis
  • A subgroup of patients with atopic dermatitis (AD) experiences recurrent herpes simplex virus infections, known as eczema herpeticum (ADEH), prompting a study of the underlying transcriptional mechanisms.
  • RNA sequencing revealed significant dysregulation in gene expression of the epidermis and dermis in ADEH patients, with a notable increase in genes related to type 2 cytokine and interferon inflammatory pathways.
  • The findings suggest that the unique inflammation and altered epidermal differentiation in ADEH patients contribute to their heightened risk for eczema herpeticum, guiding future research on this condition.
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Article Synopsis
  • Some patients with atopic dermatitis (AD) can get really bad skin infections from the herpes virus called eczema herpeticum (EH).
  • Researchers studied the skin and immune system of people with AD, both with and without EH, to find out what's happening at the gene level.
  • They discovered that those with EH have different gene expressions, leading to inflammation in the skin and problems with skin barrier functions.
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Skin biopsies are commonly used for the assessment of skin pathology in various skin diseases, including atopic dermatitis (AD). However, because of the invasive nature of skin biopsies, many patients, particularly children, decline participation. This can lead to potential subject sampling bias as data could be skewed toward more severe, older patients who are willing to have biopsies.

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Background: Expression profiling of skin biopsy specimens has established molecular features of the skin in patients with atopic dermatitis (AD). The invasiveness of biopsies has prevented their use in defining individual-level AD pathobiological mechanisms (endotypes) in large research studies.

Objective: We sought to determine whether minimally invasive skin tape strip transcriptome analysis identifies gene expression dysregulation in AD and molecular disease endotypes.

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