Publications by authors named "Caroline Brackel"
Article Synopsis
- The study aimed to investigate the prevalence of Pediatric Post-COVID-19 Condition (PPCC), identify associated risk factors, and evaluate the quality of life in children based on the severity of their acute COVID-19 illness.
- A total of 579 children participated, with 260 experiencing mild COVID-19, 60 with severe disease, and 259 as a control group; results indicated that those with severe COVID-19 had a significantly higher prevalence of PPCC compared to mild cases and controls.
- Findings showed that while prevalence of PPCC decreased over time, children exhibiting PPCC had worse physical health-related quality of life and fatigue, with risk factors including prior health issues, hospitalizations, and ongoing fatigue one month post-infection.
Post-COVID-19 condition in children is a still largely unknown syndrome with a diverse pattern of symptoms, which can have a major impact on daily life. Currently, there are no evidence-based proven treatments, and the focus is on symptom management and recovery of daily functioning. A multidisciplinary, tailored approach is recommended, with attention to energy management and activity building, where the main goal should be a return to baseline levels of cognitive, physical and social activity.
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- Pediatric post coronavirus disease 2019 (COVID-19) condition (PPCC) is a complex syndrome affecting children's daily lives, and this study aimed to uncover specific phenotypes to improve understanding and treatment.
- Researchers analyzed data from 111 children aged 3-18 with diagnosed PPCC, identifying three distinct clusters based on symptoms and demographics.
- The study found variations in age, sex, symptom patterns, and daily life impact among the clusters, emphasizing the need for further research into the diverse causes of post-COVID symptoms in children.
The coronavirus disease 2019 (COVID-19) pandemic substantially impacted different age groups, with children and young people not exempted. Many have experienced enduring health consequences. Presently, there is no consensus on the health outcomes to assess in children and young people with post-COVID-19 condition.
View Article and Find Full Text PDFEvent rates and incidence of post-COVID-19 condition in hospitalised SARS-CoV-2 positive children and young people and controls across different pandemic waves: exposure-stratified prospective cohort study in Moscow (StopCOVID).
BMC Med
February 2024
Article Synopsis
- - The study aimed to explore long-term health outcomes in children and young people post-COVID-19, particularly focusing on post-COVID-19 condition (PCC) and incomplete recovery, comparing these outcomes with those from other non-SARS-CoV-2 infections.
- - Conducted in Moscow, researchers followed two cohorts of pediatric patients with confirmed COVID-19 from two different time periods (Wuhan and Omicron variants) and compared them to a reference group of those with other infections but negative for SARS-CoV-2.
- - Findings revealed that the incidence of PCC was significantly higher in the Wuhan variant group compared to the reference group, while the Omicron variant showed no significant difference in PCC outcomes when compared to the
Background: Pediatric Post-COVID-Condition (PPCC) clinics treat children despite limited scientific substantiation. By exploring real-life management of children diagnosed with PPCC, the International Post-COVID-Condition in Children Collaboration (IP4C) aimed to provide guidance for future PPCC care.
Methods: We performed a cross-sectional international, multicenter study on used PPCC definitions; the organization of PPCC care programs and patients characteristics.
Article Synopsis
- A multicenter study from March 2020 to December 2022 evaluated pediatric COVID-19 cases, examining severity and risk factors in 564 hospitalized children across three countries.
- Among the hospitalized children, those over 12 and with preexisting respiratory issues were more likely to experience severe illness, while cases during the omicron variant showed milder symptoms overall.
- The study emphasizes that real-time data collection is crucial for guiding public health decisions, including vaccine and booster strategies for children infected with SARS-CoV-2.
Prevalence and risk factors of post-COVID-19 condition in adults and children at 6 and 12 months after hospital discharge: a prospective, cohort study in Moscow (StopCOVID).
BMC Med
July 2022
Article Synopsis
- - The study investigated the prevalence of post-COVID-19 condition (PCC) in adults and children who were hospitalized after contracting COVID-19, using a defined WHO standard and conducting follow-ups at 6 and 12 months post-discharge.
- - Findings showed a PCC prevalence of 50% in adults and 20% in children at 6 months, decreasing to 34% and 11%, respectively, at 12 months; factors such as female sex and hypertension in adults, and neurological comorbidities in children were linked to higher PCC risk.
- - The results highlight the importance of monitoring for ongoing health issues following COVID-19, particularly in higher-risk groups, as a significant number of individuals experienced
Background: Long-COVID is a well-documented multisystem disease in adults. Far less is known about long-term sequelae of COVID in children. Here, we report on the occurrence of long-COVID in Dutch children.
View Article and Find Full Text PDFGroup A streptococcal (GAS) infection can cause septic arthritis (SA), acute rheumatic fever (ARF) and post-streptococcal reactive arthritis (PSRA). Differentiating between these three entities can have important consequences for both therapy and prognosis. SA is diagnosed by means of clinical, biochemical and microbiological parameters.
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