Functional movement screen test: a reliable screening test for young elite ice hockey players.

Objectives: To determine inter-rater and intra-rater reliability of the Functional Movement Screen (FMS) test among young elite hockey players.

Design: Reliability study.

Setting: Inter-rater reliability was evaluated by two raters in the field.

Down-regulation of liver drug-metabolizing enzymes in a murine model of chronic renal failure.

Drug metabolism could be altered in patients with chronic renal failure (CRF). In rats, this phenomenon is related to a decrease in liver cytochrome P450 (P450) and phase II enzymes, particularly N-acetyltransferase 2 (NAT2). This study attempted to determine the effects of CRF on liver P450 isoforms and NAT2 expressions by using a CRF mouse model.

Down-regulation of intestinal drug transporters in chronic renal failure in rats.

Chronic renal failure (CRF) is associated with an increased bioavailability of drugs by a poorly understood mechanism. One hypothesis is a reduction in the elimination of drugs by the intestine, i.e.

Use of a fluorescent substrate for the selective quantification of rat CYP3A in the liver and the intestine.

Introduction: Quantification of cytochrome P450 is a major issue in the development of new drugs. Different assays have been reported, but few are very selective for the 3A isoform or cytochrome P450. The benzyloxy-substituted lactone cyclooxygenase-2 inhibitor 3-[(3, 4-difluorobenzyl)oxy]-5,5-dimethyl-4-[4-methylsulfonyl) phenyl] furan-2(5H)-one has recently been used successfully to probe isoform 3A of cytochrome P450 in the liver.