Publications by authors named "Caroline Berteau"
Cerebrospinal fluid (CSF) has often been used as the source of choice for biomarker discovery with the goal to support the diagnosis of neurodegenerative diseases. For this study, we selected 15 CSF protein markers which were identified in previously published clinical investigations and proposed as potential biomarkers for PD diagnosis. We aimed at investigating and confirming their suitability for early stage diagnosis of the disease.
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- Drug-induced kidney injury (DIKI) is a major issue in drug development, and traditional urinary protein biomarkers have limitations, prompting interest in microRNAs (miRNAs) as potential alternatives.
- In a study involving Wistar rats treated with three nephrotoxic substances, specific miRNAs were found to be significantly dysregulated, indicating their potential as biomarkers for kidney injury targeting different nephron segments.
- The findings suggest that combining urinary miRNAs with protein biomarkers could improve the detection of kidney damage during drug testing, enhancing our understanding of DIKI in preclinical studies.
Parkinson's Disease is the second most common neurodegenerative disorder, affecting 1-2% of the elderly population. Its diagnosis is still based on the identification of motor symptoms when a considerable number of dopaminergic neurons are already lost. The development of translatable biomarkers for accurate diagnosis at the earliest stages of PD is of extreme interest.
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