Quality of life and utility decrement associated with Clostridium difficile infection in a French hospital setting.

Background: Clostridium difficile infection (CDI) is associated with a substantial Quality of life impact on patients that has not been so far measured with a generic validated instrument.

Methods: A prospective study was performed in 7 French acute-care settings in patients presenting with a bacteriologically-confirmed CDI. The EQ-5D-3 L was filled in by patients at 7 ± 2 days after CDI diagnosis to describe their state of health at that date as well as their state of health immediately before the CDI episode (baseline).

Systemic antifungal therapy for proven or suspected invasive candidiasis: the AmarCAND 2 study.

Background: In the context of recent guidelines on invasive candidiasis (IC), how French intensive care units (ICUs) are managing IC?

Methods: This is a prospective observational multicenter cohort study. During 1 year (2012-2013), 87 French ICUs enrolled consecutive patients with suspected or proven IC (SIC or PIC) and receiving systemic antifungal therapy (SAT). Data were collected up to 28 days after inclusion.