Publications by authors named "Caroline A Perry"
Environ Health Perspect
April 2021
Article Synopsis
- Mitochondrial damage from environmental toxicants can trigger inflammation through the activation of the NLRP3 inflammasome, which is linked to various inflammatory disorders.
- The study aimed to assess whether mitochondrial toxicants cause this inflammasome activation, using specific organotins to test their effects on macrophage cells.
- Results showed that exposure to the toxicants led to inflammasome formation and impaired mitochondrial function, alongside changes in gene expression and signaling pathways associated with inflammation and apoptosis.
