Publications by authors named "Caroline A Cypranowska"
Weakening of synaptic transmission at the Drosophila larval neuromuscular junction triggers two forms of homeostatic compensation, one that increases the probability of glutamate release per action potential (Pr) and another that increases motoneuron (MN) activity. We investigated the molecular changes in MNs that underlie the increase in MN activity. RNA-seq analysis on MNs whose glutamate release is weakened by knockdown of components of the MN transmitter release machinery reveals a reduction in expression of a group of genes that encode potassium channels and their positive modulators.
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- * A study on dynein from yeast showed that introducing specific pauses in its movement revealed that AAA3 hydrolyzes ATP much slower than AAA1 and that both ATPase sites do not work together.
- * Mutations in AAA3 affected dynein's ability to release from microtubules, indicating that AAA3 functions like a switch to facilitate fast cargo transport and helps anchor dynein to microtubules.