Reversible tonic pupils.

A 36-year-old man with a remote history of Hodgkin lymphoma and a recent history of non-Hodgkin lymphoma (NHL) developed tonic pupils and absent deep tendon reflexes in the lower extremities. One year later, pupils were normal except for slight iris segmental contraction to light. Over the next 2 years, the patient remained asymptomatic, and pupils remained unchanged.

Blood pressure, arterial stiffness, and open-angle glaucoma: the Rotterdam study.

Objective: To investigate cross-sectional associations among blood pressures (BPs), arterial stiffness, and open-angle glaucoma (OAG).

Methods: Study participants came from the population-based Rotterdam Study. The baseline examination phase took place after an extensive home interview from March 20, 1990, to June 17, 1993, and the third phase between March 19, 1997, and December 16, 1999.

Value of routine funduscopy in patients with hypertension: systematic review.

Objective: To evaluate the additional value of funduscopy in the routine management of patients with hypertension.

Design: Systematic review.

Participants: Adults aged 19 or more with hypertensive retinopathy.

Is there a direct association between age-related eye diseases and mortality? The Rotterdam Study.

Purpose: To study mortality in subjects with age-related maculopathy (ARM), cataract, or open-angle glaucoma (OAG) in comparison with those without these disorders.

Design: Population-based prospective cohort study.

Participants: Subjects (n = 6339) aged 55 years and older from the population-based Rotterdam Study for whom complete information on eye disease status was present.

Family score as an indicator of genetic risk of primary open-angle glaucoma.

Objectives: To assess the genetic risk of open-angle glaucoma (OAG) in individuals by calculating a family score (FS), which summarizes the information of all relatives including their disease status, age, sex, and degree of kinship and to examine the genetic contribution to OAG with and without an increased intraocular pressure.

Methods: Case and control probands, derived from the Rotterdam Study, underwent the same ophthalmologic examination as their relatives. The FS of each proband was the sum of the differences between observed and expected values of OAG for all relatives.

Myocilin mutations in a population-based sample of cases with open-angle glaucoma: the Rotterdam Study.

Purpose: To investigate the prevalence of myocilin (MYOC) mutations in a population-based sample of open-angle glaucoma (OAG) cases and to describe a family with both juvenile and adult onset OAG caused by a mutation in MYOC.

Methods: MYOC was screened in cases derived from the Rotterdam Study in the Netherlands. Definite OAG was defined as a glaucomatous optic neuropathy together with a glaucomatous visual field defect.