Publications by authors named "Carolina Trevisolli Palomo"
Article Synopsis
- Tuberculous meningitis (TBM) is a severe form of tuberculosis, and a review of studies was conducted to understand its impact on adults in high TB incidence countries.
- Out of 11,855 articles searched, 21 were reviewed, and 15 included in the meta-analysis, revealing a 25% overall mortality rate and a staggering 70% death rate in Africa.
- The study found inconsistencies in diagnostic methods and treatment approaches, indicating a pressing need for standardized guidelines to improve diagnosis and treatment to lower mortality rates, especially in African regions.
Article Synopsis
- This study focused on synthesizing 22 salicylhydrazone derivatives to test their effectiveness as new anti-TB drugs in vitro.
- Three compounds (10, 11, and 18) were highlighted for their promising results, with compound 18 showcasing the best activity against Mycobacterium tuberculosis at a low MIC of 0.49 μg/mL and good safety profile.
- The compounds exhibited cooperative effects when tested with existing TB drugs and showed potential against both drug-susceptible and resistant strains, particularly compound 18 which stood out due to its low cytotoxicity.
To review , , and studies examining the antibacterial and immunomodulatory properties of piperine (PPN). This systematic review followed PRISMA guidelines, and five databases were searched. A total of 40 articles were included in this study.
View Article and Find Full Text PDFBinding of piperine to mycobacterial RNA polymerase improves the efficacy of rifampicin activity against and nontuberculous mycobacteria.
Letícia Sayuri Murase Diego de Souza Lima João Vítor Perez de Souza Carolina Trevisolli Palomo Katiany Rizzieri Caleffi-Ferracioli
J Biomol Struct Dyn
October 2022
Piperine (PPN) is a known inhibitor of efflux pumps in and synergism with rifampicin (RIF) has been proven. The current study evaluates the activity of PPN and synergism with RIF in rapidly and slowly growing nontuberculous mycobacteria (NTM). Also, to propose a possible mechanism of interaction of PPN with (Mlp) RNA polymerase (RNAp).
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