Publications by authors named "Carolina Santos Dos Passos"
Indole alkaloids and semisynthetic indole derivatives as multifunctional scaffolds aiming the inhibition of enzymes related to neurodegenerative diseases--a focus on Psychotria L. Genus.
Luiz Carlos Klein Carolina Santos Dos Passos Aline Pereira Moraes Vinicius Galvao Wakui Eduardo Luis Konrath
Curr Top Med Chem
December 2014
Article Synopsis
- Indole alkaloids and synthetic derivatives are recognized for their therapeutic potential, particularly in inhibiting enzymes linked to neurodegenerative diseases, such as AChE, BChE, and MAOs.
- The study highlights specific alkaloids from the Psychotria L. genus and evaluates in vitro their effectiveness in inhibiting MAO-A, with two synthetic derivatives showing significant activity.
- Molecular docking studies reveal how the indole structures of these compounds interact with MAO-A, suggesting their potential as scaffolds for designing new neuroprotective MAO-A inhibitors.