Publications by authors named "Carolina Santos Dos Passos"
Curr Top Med Chem
December 2014
Article Synopsis
- Indole alkaloids and synthetic derivatives are recognized for their therapeutic potential, particularly in inhibiting enzymes linked to neurodegenerative diseases, such as AChE, BChE, and MAOs.
- The study highlights specific alkaloids from the Psychotria L. genus and evaluates in vitro their effectiveness in inhibiting MAO-A, with two synthetic derivatives showing significant activity.
- Molecular docking studies reveal how the indole structures of these compounds interact with MAO-A, suggesting their potential as scaffolds for designing new neuroprotective MAO-A inhibitors.
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