Publications by authors named "Carolina Rocha Silva"
Resistant nematodes are not affected by the most common drugs commercially available. In the search for new anthelmintics, peptides have been investigated. Here, a linear synthetic peptide named -PepIII bioinspired from the antimicrobial protein was designed, synthesized, and tested against barber pole worm .
View Article and Find Full Text PDFHigh levels of immunosuppression are related to unfavourable outcomes in hospitalised patients with rheumatic diseases and COVID-19: first results of ReumaCoV Brasil registry.
RMD Open
January 2021
Article Synopsis
- This study aimed to identify risk factors for severe outcomes (like hospitalization and death) in patients with immune-mediated rheumatic diseases (IMRD) who contracted COVID-19.
- Out of 334 patients observed, key findings showed that age over 50, use of certain immunosuppressive treatments, and underlying conditions (like diabetes and kidney disease) increased the risk of emergency care and hospitalization, while treatments with TNF inhibitors were potentially protective.
- The analysis concluded that older age and specific immunosuppressive therapies are linked to worse COVID-19 outcomes, emphasizing the importance of tailored treatment strategies for these patients.
Essential oil from the leaves of L. (Compositae) cultivated in Brazil was investigated for its chemical composition and biological activities including antibacterial, antifungal, and anthelmintic. The constituents of essential oils isolated by hydro-distillation were examined by GC-MS and a total of 18 components were identified.
View Article and Find Full Text PDFGastrointestinal nematodes are a significant concern for animal health and well-being, and anthelmintic treatment is mainly performed through the use of chemical products. However, bioactive compounds produced by plants have shown promise for development as novel anthelmintics. The aim of this study is to assess the anthelmintic activity of protein fractions from Spigelia anthelmia on the gastrointestinal nematode Haemonchus contortus.
View Article and Find Full Text PDFIntroduction: Patients with a diagnosis of rheumatoid arthritis (RA) are at increased risk of infections. Vaccination is a recommended preventive measure. There are no studies evaluating the practice of vaccination in patients with early RA.
View Article and Find Full Text PDFObjective: To determine the prevalence of sexual dysfunction in women diagnosed with early rheumatoid arthritis (RA) (less than one year of symptoms at the time of diagnosis), as well as to evaluate the possible association between sexual dysfunction with AR activity and functional disability.
Methods: Cross-sectional study assessing women diagnosed with early RA, accompanied per protocol in the Brasilia Cohort, Hospital Universitário de Brasília. Demographics, disease activity index (Disease Activity Score 28 - DAS 28) and functional disability questionnaire (Health Assessment Questionnaire - HAQ), were obtained by direct interviews.
Introduction: The 2012 Consensus of the Brazilian Society of Rheumatology (SBR) for the treatment of Rheumatoid Arthritis (RA) recommends that patients should regularly perform physical exercises. There have been no studies in Brazil on physical activity among patients with early RA.
Objective: To investigate the physical activity practice among patients with early RA and the possible association between physical activity, disease activity and functional disability.