Publications by authors named "Carolina Riemer"
Immunoglobulin G (IgG) antibodies are major drivers of inflammation during infectious and autoimmune diseases. In pooled serum IgG (IVIg), however, antibodies have a potent immunomodulatory and anti-inflammatory activity, but how this is mediated is unclear. We studied IgG-dependent initiation of resolution of inflammation in cytokine- and autoantibody-driven models of rheumatoid arthritis and found IVIg sialylation inhibited joint inflammation, whereas inhibition of osteoclastogenesis was sialic acid independent.
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- Researchers have identified autoantibodies against myelin oligodendrocyte glycoprotein (MOG) as a key factor in a new disease called MOG-antibody-associated disease (MOGAD), which resembles multiple sclerosis.
- The study explores how these MOG-specific antibodies damage the nervous system, focusing on the roles of complement proteins and Fc-receptors.
- Findings show that both mechanisms contribute equally to nerve damage, while the activation of certain immune cells in the brain depends specifically on FcR interactions, suggesting potential targets for new treatments.