Publications by Carolina Pein

Publications by authors named "Carolina Pein"

Infect Dis Ther

May 2024

Ritonavir is a strong inhibitor of the cytochrome P450 3A4 enzyme, mainly used to increase the effectiveness of other antiviral drugs by enhancing their bioavailability.
Studies show that ritonavir is generally safe and well-tolerated in HIV and COVID-19 treatments, even at boosted doses.
While ritonavir can lead to potential drug-drug interactions (DDIs), the overall risk with contraindicated medications is low, allowing healthcare specialists to effectively manage co-medication issues.

- Carolina Pein's recent research focuses on the pharmacokinetic (PK) management of ritonavir, emphasizing its role as a potent enhancer in antiviral therapies, particularly for HIV and COVID-19 treatment.
- The 25-year narrative review highlights the well-established safety profile and tolerability of boosting doses of ritonavir, indicating its long-term effectiveness in clinical applications.
- Pein also addresses the implications of drug-drug interactions (DDIs) associated with ritonavir, underlining the importance of careful co-medication management in enhanced antiviral therapy regimens.