Publications by authors named "Carolina P da Silva"
Characterization of a novel acidic phospholipase A isolated from the venom of Bothrops mattogrossensis: From purification to structural modeling.
Int J Biol Macromol
December 2024
Phospholipases A (PLAs) are highly prevalent in Bothrops snake venom and play a crucial role in inflammatory responses and immune cell activation during envenomation. Despite their significance, the specific role of PLAs from Bothrops mattogrossensis venom (BmV) in inflammation is not fully understood. This study sought to isolate and characterize a novel acidic PLA from BmV, designated BmPLA-A, and to evaluate its effects on human umbilical vein endothelial cells (HUVECs), with a specific focus on cytotoxicity, adhesion, and detachment.
View Article and Find Full Text PDFArticle Synopsis
- The study examined how Bothrops atrox venom (BaV) affects the maturation of bone marrow-derived dendritic cells (BMDCs) from mice, focusing on cell markers and cytokine release.
- BMDCs, which play a key role in initiating immune responses, were influenced by the culture environment and additional stimuli like BaV and LPS, showing changes in surface marker expression indicative of maturation.
- BaV exposure led to a decrease in key markers for T cell activation, suggesting it may impair the immune system's adaptive response, while also causing selective cytokine release that modifies inflammatory responses.
Applicability of terahertz spectroscopy in dentistry: a scoping review.
Oral Surg Oral Med Oral Pathol Oral Radiol
November 2024
Objective: This study aimed to analyze the scope, nature, and extent of the applicability of terahertz (THz) spectroscopy in dentistry.
Study Design: A scoping review was conducted following the 5-step methodology of Arksey and O'Malley, the PRISMA-ScR checklist, and the Evidence Synthesis Manual of the Joanna Briggs Institute. Electronic literature searches were performed in the PubMed/MEDLINE, Scopus, and Cochrane Library databases, including full-text articles with no specific publication period.
BjussuMP-II, a venom metalloproteinase, induces the release and cleavage of pro-inflammatory cytokines and disrupts human umbilical vein endothelial cells.
Chem Biol Interact
May 2024
Snake venom metalloproteases (SVMPs) are hydrolytic enzymes dependent on metal binding, primarily zinc (Zn), at their catalytic site. They are classified into three classes (P-I to P-III). BjussuMP-II, a P-I SVMP isolated from Bothrops jararacussu snake venom, has a molecular mass of 24 kDa.
View Article and Find Full Text PDFContext: Although the high incidence of gastroesophageal reflux disease (GERD) in the population, there is much controversy in this topic, especially in the surgical treatment. The decision to use of a total or partial fundoplication in the treatment of GERD is still a challenge to many surgeons because the few evidence found in the literature.
Objective: To bring more clear evidence in the comparison between total and partial fundoplication.