O-Linked GlcNAcylation mediates the inhibition of proximal tubule (Na+K)ATPase activity in the early stage of diabetes mellitus.

Background: Diabetic kidney disease (DKD) is a severe complication of diabetes mellitus (DM). It has been proposed that modifications in the function of proximal tubule epithelial cells (PTECs) precede glomerular damage during the onset of DKD. This study aimed to identify modifications in renal sodium handling in the early stage of DM and its molecular mechanism.