Negative affect instability predicts elevated depressive and generalized anxiety disorder symptoms even when negative affect intensity is controlled for: an ecological momentary assessment study.

Introduction: Mood and anxiety disorders are characterized by abnormal levels of positive affect (PA), negative affect (NA) and changes in how emotions unfold over time. To better prevent and treat those disorders, it is crucial to determine which kind of indices of emotion dynamics best predict elevated depressive and generalized anxiety symptoms.

Methods: 221 individuals (60 men; mean age = 46 years, SD = 15 years) completed a 7-day ecological momentary assessment study, where their positive and negative affective experience was assessed 5 times a day.

Estonian National Mental Health Study: Design and methods for a registry-linked longitudinal survey.

Objectives: The Estonian National Mental Health Study (EMHS) was conducted in 2021-2022 to provide population-wide data on mental health in the context of COVID-19 pandemic. The main objective of this paper is to describe the rationale, design, and methods of the EMHS and to evaluate the survey response.

Methods: Regionally representative stratified random sample of 20,000 persons aged 15 years and older was drawn from the Estonian Population Register for the study.

Causal contributions of human frontal eye fields to distinct aspects of decision formation.

Several theories propose that perceptual decision making depends on the gradual accumulation of information that provides evidence in favour of one of the choice-options. The outcome of this temporally extended integration process is thought to be categorized into the 'winning' and 'losing' choice-options for action. Neural correlates of corresponding decision formation processes have been observed in various frontal and parietal brain areas, among them the frontal eye-fields (FEF).

Variants of TPH2 interact with fast visual processing as assessed by metacontrast.

Sensitivity to threatening or otherwise unpleasant visual stimuli has become a widely used measure of potential vulnerability/resilience. Basically, experiments using this strategy present brief stimuli, often followed by a mask, and individuals' sensitivity is measured. However, it has not been asked whether the individual differences in threat detection or adaptive resilience associated with genetic variability-related endophenotypes might be just a function of some basic visual functions involved in processing and reporting brief visual stimuli without any emotional content.

Brain dopaminergic system related genetic variability interacts with target/mask timing in metacontrast masking.

Dopaminergic system of the brain is believed to be strongly involved in normal and pathological behavioral phenotypes of attention. In metacontrast masking studies attentional effects on metacontrast are predominantly expressed when time intervals between a target stimulus and a masking stimulus are longer rather than shorter. Taken together, this predicts that variability in common genes known to be involved in dopaminergic function could interact with target/mask intervals in determining the effects of metacontrast masking.

Visual evoked potentials to change in coloration of a moving bar.

In our previous study we found that it takes less time to detect coloration change in a moving object compared to coloration change in a stationary one (Kreegipuu etal., 2006). Here, we replicated the experiment, but in addition to reaction times (RTs) we measured visual evoked potentials (VEPs), to see whether this effect of motion is revealed at the cortical level of information processing.

Repetitive TMS over V5/MT shortens the duration of spatially localized motion aftereffect: the effects of pulse intensity and stimulation hemisphere.

Causal relevance of the cortical area V5/MT for motion (aftereffect) perception has been shown when rTMS pulses have been applied onto this area, leading to disruption of the percept. Typically, the inducing and test stimuli have consisted in a spatially contiguous area from where stimulation is presented. Observers have had no need to divide attention between spatially remote areas including motion-related signals with different vectors.

Flash-lag effect: complicating motion extrapolation of the moving reference-stimulus paradoxically augments the effect.

One fundamental property of the perceptual and cognitive systems is their capacity for prediction in the dynamic environment; the flash-lag effect has been considered as a particularly suggestive example of this capacity (Nijhawan in nature 370:256-257, 1994, Behav brain sci 31:179-239, 2008). Thus, because of involvement of the mechanisms of extrapolation and visual prediction, the moving object is perceived ahead of the simultaneously flashed static object objectively aligned with the moving one. In the present study we introduce a new method and report experimental results inconsistent with at least some versions of the prediction/extrapolation theory.

Target-mask shape congruence impacts the type of metacontrast masking.

Visual metacontrast masking may depend on the time intervals between target and mask in two qualitatively different ways: in type-A masking the smaller the mask delay from target the stronger the masking while in type-B masking maximal masking effect is obtained with a larger temporal delay of the mask. Variability in the qualitative apperance of masking functions has been explained by variability in stimuli parameters and tasks. Recent research on metacontrast masking has surprisingly shown that both of these types of functions can be found with an identical range of stimulation parameters depending on individual differences between observers.

Spatially localized motion aftereffect disappears faster from awareness when selectively attended to according to its direction.

In searching for the target-afterimage patch among spatially separate alternatives of color-afterimages the target fades from awareness before its competitors (Bachmann, T., & Murd, C. (2010).

Scotomas induced by multiple, spatially invariant TMS pulses have stable size and subjective contrast.

Transcranial magnetic stimulation (TMS) can be used for studying causal effects on visual phenomenology. Occipitally delivered TMS pulses when applied after a brief spatially extended visual reference stimulus induce a localized degrading effect on the visual quality of the reference, a subjective darkening called scotoma. The stability of the subjective characteristics of artificial scotomas has not been studied with advanced neuronavigation of TMS.

Covert spatial attention in search for the location of a color-afterimage patch speeds up its decay from awareness: introducing a method useful for the study of neural correlates of visual awareness.

Previous research has reported that attention to color afterimages speeds up their decay. However, the inducing stimuli in these studies have been overlapping, thereby implying that they involved overlapping receptive fields of the responsible neurons. As a result it is difficult to interpret the effect of focusing attention on a phenomenally projected target-afterimage.

Caffeine enhances frontal relative negativity of slow brain potentials in a task-free experimental setup.

State dependent effects on brain processes are difficult to study due to the task-related confounds. Even in simple task environments external stimuli inevitably interact with dynamically changing states of the brain. Psychopharmacological manipulation and transcranial magnetic stimulation can be used independently of variations in subject's experimental task and environmental stimulation.

Detection of colour change in moving objects: temporal order judgment and reaction time analysis.

The time needed to detect changes in the colouration of a single moving stimulus becomes shorter with its increasing velocity (Kreegipuu et al, 2006 Vision Research 46 1848-1855). We examined the ability to detect colour change in moving chromatic bars or sinusoidal gratings through temporal order judgment (TOJ) and reaction time (RT) tasks to test whether the effect of velocity found in a previous study is universal and holds for different tasks and stimuli. The results demonstrate that the TOJ and simple RT to the colour change of a moving grating are insensitive to stimulus velocity.

Detection of colour changes in a moving object.

The colour-changing stimulus paradigm is based on a tacit assumption that kinematic attributes (velocity, movement direction) do not affect the detection of colour change (). In this study three experiments are reported that clearly demonstrate that the time needed to detect changes in colouration of a moving stimulus becomes shorter with its velocity. The reduction of reaction time with increase of velocity is a purely kinematic effect independent on the reduction of reaction time caused by the stimulus uncertainty effects.