Relationships between mesopic visual sensitivity and macular inner and outer retinal layer thickness in healthy younger, middle-aged and older adults.

Purpose: To examine relationships between mesopic visual sensitivity measurements on microperimetry and macular inner and outer retinal layer (IRL and ORL) thicknesses in healthy younger, middle-aged and older subjects.

Methods: In total, 154 healthy adults were divided into three age groups each with similar mean sensitivity. Regional retinal sensitivity (determined by mesopic fundus-controlled microperimetry) and IRL (ganglion cell-related layer) and ORL thicknesses were measured in the five subfields: central fovea (1 mm diameter) and the quadrants temporal, nasal, superior and inferior of a parafoveal ring of outer diameter 3 mm and inner diameter 1 mm.