Analysis of motor, cognitive and language performance of infants undergoing treatment for congenital hypothyroidism.

Objective: Investigate the association between the age of treatment onset and confirmatory TSH level (as an indicator of severity) with a greater risk of developmental delay in infants with congenital hypothyroidism (CH).

Method: The authors conducted a cross-sectional, observational, unmatched case-control study at a Brazilian neonatal screening reference center. Seventy-seven infants with CH (mean age: 12 ± 6.

Prevalence of Testicular Adrenal Rest Tumor and Factors Associated with Its Development in Congenital Adrenal Hyperplasia.

Background: Testicular adrenal rest tumors (TART) can cause infertility in congenital adrenal hyperplasia (CAH) males.

Aims: To determine TART prevalence in patients with CAH due to 21-hydroxylase deficiency (21-OHD) and evaluate possible factors associated with its development.

Methods: This is a descriptive and analytical cross-sectional study evaluating males with the classical form of 21-OHD through testicular ultrasonography and serum inhibin B dosages.

Neonatal screening: 9% of children with filter paper thyroid-stimulating hormone levels between 5 and 10μIU/mL have congenital hypothyroidism.

Objectives: To determine the prevalence of congenital hypothyroidism in children with filter-paper blood-spot TSH (b-TSH) between 5 and 10μIU/mL in the neonatal screening.

Methods: This was a retrospective study including children screened from 2003 to 2010, with b-TSH levels between 5 and 10μIU/mL, who were followed-up during the first two years of life when there was no serum TSH normalization. The diagnosis of congenital hypothyroidism was defined as serum TSH ≥10μIU/mL and start of levothyroxine treatment up to 2 years of age.

[MRI findings in Rasmussen's encephalitis].

Introduction: Rasmussen's encephalitis is a chronic inflammatory encephalitis of unknown etiology. Clinical, imaging and electroencephalographic characteristic findings allow its diagnosis. Serial brain MRI evaluation of these patients has a characteristic pattern of temporal evolution.

[Benign fibro-osseous lesions of the craniofacial complex with aneurysmal bone cyst formation].

Aneurysmal bone cyst are controversial osteolytic benign expansive lesions which occur more frequently in the metaphysis of long bones and spine. They are classified as primary or secondary lesions depending on the presence or absence of an associated bone pathology. The engraftment of aneurysmal bone cyst onto benign fibro-osseous lesions is established.

[Acute cerebellitis in children: regarding different etiologies].

Unlabelled: Acute cerebellitis is usually infectious, post-infectious or post-vaccination. Rarer causes include toxic ones. The clinical presentation is usually benign, however, severe cases with brainstem compression may present as coma.

Accuracy of anthropometric measurements in estimating fat mass in individuals with 21-hydroxylase deficiency.

Objective: The use of anthropometric measurements to estimate the percentage of body fat (%BF) is easy and inexpensive. However, the accuracy of these methods in patients with 21-hydroxylase deficiency (21OHD) has not been explored. The objective of this study was to evaluate the accuracy of skinfold-based models, body mass index (BMI), and waist circumference (WC) in estimations of %BF using dual-energy X-ray absorptiometry (DXA) as the reference method in individuals with 21OHD.

Normalization of height and excess body fat in children with salt-wasting 21-hydroxylase deficiency.

Objective: To evaluate growth and body composition of patients with the salt wasting form of classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency and to compare them with healthy children.

Methods: Twenty-one prepubertal patients (eight boys and 13 girls) between 2.1 and 10.