Publications by authors named "Carolina Mastella Botelho"
Identification of a CTX-M-255 β-lactamase containing a G239S substitution selectively conferring resistance to penicillin/β-lactamase inhibitor combinations.
Minna Rud Andreasen Tim Rick Nicolai Riff Alexandersen Katrine Hartung Hansen Martin Schou Pedersen Carolina Mastella Botelho
J Antimicrob Chemother
April 2024
Objectives: An Escherichia coli isolate, WGS1363, showed resistance to piperacillin/tazobactam but susceptibility to cephalosporins and contained a previously unrecognized β-lactamase, CTX-M-255, as the only acquired β-lactamase. CTX-M-255 was identical to CTX-M-27 except for a G239S substitution. Here, we characterize the hydrolytic spectrum of CTX-M-255 and a previously reported β-lactamase, CTX-M-178, also containing a G239S substitution and compare it to their respective parental enzymes, CTX-M-27 and CTX-M-15.
View Article and Find Full Text PDFArticle Synopsis
- Advances in malaria control have been seen in Africa, but hotspots of high transmission remain a threat due to inadequate surveillance and high costs of direct estimates.
- Researchers used genetic data to study malaria prevalence and transmission dynamics in the remote Makira region of Madagascar, involving 698 individuals and multiple seasonal tests.
- The study found a 27.8% infection rate for P. falciparum in Makira, significantly higher than the national average, and noted a high level of genetic diversity among infections, indicating stable and high transmission in the area.