Publications by authors named "Carolina Maldonado"

The rise of antibiotic-resistant bacteria in clinical settings has become a significant global concern. Among these bacteria, stands out due to its remarkable ability to acquire resistance genes and persist in hospital environments, leading to some of the most challenging infections. Horizontal gene transfer (HGT) plays a crucial role in the evolution of this pathogen.

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Introduction: The efficiency of The International Classification of Headache Disorders (ICHD-3) in reflecting patients' disability has recently been questioned. This prompts consideration that clinical features beyond pain may more accurately indicate the extent of underlying brain impairment than the mere frequency of headache days. Important cognitive dysfunctions and psychological impairment have been reported in burdensome cases of migraine, and the presence of these alterations has been associated with biological changes in the nervous system.

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  • Streptococcal toxic shock syndrome (STTS) is a severe medical emergency characterized by rapid symptom onset and high risks of morbidity and mortality, highlighting the need for quick recognition and intervention.
  • A study observed 13 patients at Vall d'Hebron University Hospital with invasive infections, primarily community-acquired pneumonia and skin infections, all receiving immediate antibiotic treatment and various organ support therapies.
  • The research identified three patient phenotypes (hyperinflammatory, low perfusion, hypogammaglobulinemic) that could help tailor personalized treatments, stressing the importance of combining rapid antibiotics and strategic source control to improve survival outcomes.
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  • This case report discusses a patient with Hemophagocytic lymphohistiocytosis (HLH) triggered by NK-type non-Hodgkin lymphoma and Epstein-Barr virus, leading to severe organ dysfunction and shock.
  • Comprehensive diagnostic tests, including a liver biopsy and bone marrow aspirate, confirmed the HLH diagnosis, and the patient met the HLH-2004 criteria.
  • Treatment included corticosteroids and etoposide, along with cytokine hemoadsorption, which dramatically improved the patient's hemodynamics and reduced the need for vasopressive medications.
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Background: Human metapneumovirus (HMPV) is an important aetiologic agent of respiratory tract infection (RTI). This study aimed to describe its genetic diversity and clinical impact in patients attended at a tertiary university hospital in Barcelona from the 2014-2015 to the 2016-2017 seasons, focusing on the emerging duplications in G gene and their structural properties.

Methods: Laboratory-confirmed HMPV were characterised based on partial-coding F and G gene sequences with MEGA.

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Children in situations of destitution who become institutionalized commonly display developmental disorders, including delayed growth. The aim was to evaluate the environmental quality of the of the Department of Chuquisaca (Plurinational state of Bolivia) in children aged 0 to 2 years old after receiving an early stimulation program based on psychomotor therapy. Thirty-six children who were institutionalized at shelter homes in the Department of Chuquisaca were selected to receive sessions of psychomotricity over a five-month period.

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In the present study, the synthesis of an organic group-modified alumina by the sol-gel method is proposed. This material has shown to have an enhanced catalytic performance with grafted organic groups and showed an improved stability. The prepared material has shown to have several groups and an enhanced surface acidity.

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Objectives: Refractory hypoxaemia is the leading cause of mortality in the postoperative period after lung transplantation. The role of prone positioning as a rescue therapy in this setting has not been assessed. We evaluated its effects in lung transplant recipients presenting refractory hypoxaemia following the surgery.

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Major signaling molecules initially characterized as key early developmental regulators are also essential for the plasticity of the nervous system. Previously, the Wingless (Wg)/Wnt pathway was shown to underlie the structural and electrophysiological changes during activity-dependent synaptic plasticity at the neuromuscular junction. A challenge remains to understand how this signal mediates the cellular changes underlying this plasticity.

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The role of iron in two modes of integration into alumina catalysts was studied at 0.39 wt% Fe and tested in trichloroethylene combustion. One modified alumina was synthesized using the sol-gel method with Fe added in situ during hydrolysis; another modification was performed using calcined alumina, prepared using the sol-gel method and impregnated with Fe.

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RNA editing is a powerful way to recode genetic information. Because it potentially affects RNA targets that are predominantly present in neurons, it is widely hypothesized to affect neuronal structure and physiology. Across phyla, loss of the enzyme responsible for RNA editing, Adar, leads to behavioral changes, impaired locomotion, neurodegeneration and death.

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