Publications by authors named "Carolina Kanig"
Article Synopsis
- This study explores how lying and sexual arousal affect motor cortex excitability in heterosexual men and women using motor-evoked potentials (MEPs) while they view arousing images.* -
- Sixteen heterosexual couples participated in a series of trials where they viewed suggestive images and had to answer questions either truthfully or dishonestly regarding their preferences.* -
- Results indicated that while both men and women showed higher excitability towards their preferred sexual stimuli, lying increased cortical excitability; however, MEPs are not reliable indicators for diagnosing sexual preference or related conditions.*
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique capable of inducing neuroplasticity as measured by changes in peripheral muscle electromyography (EMG) or electroencephalography (EEG) from pre-to-post stimulation. However, temporal courses of neuromodulation during ongoing rTMS are unclear. Monitoring cortical dynamics via TMS-evoked responses using EMG (motor-evoked potentials; MEPs) and EEG (transcranial-evoked potentials; TEPs) during rTMS might provide further essential insights into its mode of action - temporal course of potential modulations.
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- - The study investigates variations in transcranial magnetic stimulation (TMS) pulse widths among different pulse sources and stimulation intensities, revealing significant differences in average pulse widths compared to manufacturer specifications.
- - Seven MagVenture® pulse sources were tested, with results showing a mean pulse width of 288.11s, deviating slightly from the expected 280s value; however, variability was low within groups.
- - A pilot experiment indicated no significant impact of pulse width on motor evoked potential amplitude but showed differences in latencies, suggesting further research is needed to explore the physiological implications of varied pulse lengths and other factors like hardware aging.
Background: Motor hotspot identification represents the first step in the determination of the motor threshold and is the basis for the specification of stimulation intensity used for various Transcranial Magnetic Stimulation (TMS) applications. The level of experimenters' experience and the methodology of motor hotspot identification differ between laboratories. The need for an optimized and time-efficient technique for motor hotspot identification is therefore substantial.
View Article and Find Full Text PDFIntroduction: Repetitive transcranial magnetic stimulation (rTMS) is used to induce long-lasting changes (aftereffects) in cortical excitability, which are often measured via single-pulse TMS (spTMS) over the motor cortex eliciting motor-evoked potentials (MEPs). rTMS includes various protocols, such as theta-burst stimulation (TBS), paired associative stimulation (PAS), and continuous rTMS with a fixed frequency. Nevertheless, subsequent aftereffects of rTMS are variable and seem to fail repeatability.
View Article and Find Full Text PDFAims: Motor evoked potentials (MEP) elicited by transcranial magnetic stimulation (TMS) over the primary motor cortex are used as a neurophysiological marker of cortical excitability in clinical and scientific practice. Though, the reliability of this outcome parameter has not been clarified. Using a systematic approach, this work reviews and critically appraises studies on the reliability of MEP outcome parameters derived from hand muscles of healthy subjects and gives a proposal for most reliable TMS practice.
View Article and Find Full Text PDFObjective: The aim of this study was to investigate the reliability of low-frequency and high-frequency repetitive transcranial magnetic stimulation (rTMS) on healthy individuals over the motor cortex. A secondary outcome was the assessment if low-frequency rTMS results in inhibition and high-frequency rTMS results in facilitation.
Methods: In this experiment, 30 healthy participants received on four consecutive days one session each with application of 1 Hz or 20 Hz rTMS over the left motor cortex.
Introduction: There is a need for novel anxiolytics with improved side effect profiles compared to benzodiazepines. A promising candidate with alternative pharmacodynamics is the translocator protein ligand, etifoxine.
Methods: To get further insight into its mechanisms of action and side effects compared to the benzodiazepine alprazolam, we performed a double-blind, placebo-controlled, repeated-measures study in 36 healthy male subjects.