Publications by authors named "Carolina Flausino"
Objective: The aim of this multicentric study was to assess the diagnostic accuracy of a telediagnosis service for oral mucosal disorders.
Study Design: This study included 100 patients seen at the oral medicine outpatient clinic of 3 Brazilian Dental Schools (University of Campinas, Federal University of Pernambuco, and Federal University of Santa Catrina) from March 2019 to October 2019. In addition to the face-to-face assistance provided by graduate students and the final diagnosis validated by the professors of these institutions, a remote evaluation was requested for these patients through the EstomatoNet/TelessaúdeRS platform.
Article Synopsis
- The study analyzed the 100 most-cited articles on intraoral squamous cell carcinoma and its risk factors using bibliometric data collected from the Web of Science database.
- Most of the articles, published between 1950 and 2017, were case-control studies, with a significant emphasis on alcohol, tobacco, and human papillomavirus as major risk factors.
- The research highlighted that the United States, the United Kingdom, and France were the leading contributors, with S. Franceschi and the International Agency for Research on Cancer being the most prominent authors and institutions.
DNA methylation is one of epigenetic changes most frequently studied nowadays, together with its relationship with oral carcinogenesis. A group of enzymes is responsible for methylation process, known as DNA methyltransferases (DNMT). Although essential during embryogenesis, DNA methylation pattern alterations, including global hypomethylation or gene promoter hypermethylation, can be respectively associated with chromosomal instability and tumor suppressor gene silencing.
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